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Publications

2022

56.

Precision Control Of The Half-Life Of CRISPR-Based Systems In Vivo​

V. Sreekanth, M. Jan, K. T. Zhao, D. Lim, J. R. Davis, M. McConkey, V. Kovalcik, S. Barkal, B. K. Law, J. Fife, R. Tian, M. E. Vinyard, B. Becerra, M. Kampmann, R. I. Sherwood, L. Pinello, D. R. Liu, B. L. Ebert, A. Choudhary

Submitted

55.

Induction Of Tyrosine Phosphorylation By Chimeric Small Molecules

R. Pergu, V. M. Shoba, S.K. Chaudhary, D. N. P. M. Godage, A. Deb, S. Singha, V. Anokhina, S. A. Singh, U. Dhawa,  S. U. Siriwardena, A. Choudhary

 

 

54.

Isoform-Specific Recruitment Of Kinases For Phosphorylation Induction

S. Lai, R. Pergu, P. Kokkonda, P. Tiwari, A. Choudhary

 

53.

Homo-dimerization mediated kinase inhibition using bifunctional molecules

52.

A multiplexed platform enables systematic interogation of fatty acid biology and uncovers mechanism of lipotoxicity

Under review

51.

A general approach to identify cell-permeable and synthetic anti-cRISPR small molecules

D. Lim, Q. Zhou, K. J. Cox, B. K. Law, M. Lee, P. Kokkonda, V. Sreekanth, R. Pergu, S. K. Chaudhary, S. A. Gangopadhyaya, B. Maji, S. Lai, Y. Amako, D. B. Thompson, H. K. Subramanian, M. F. Mesleh, V. Dancik, P. A. Clemons, B. K. Wagner, C. M. Woo, G. M. Church, A. Choudhary

Nature Cell Biology. In Press


50.

Synthetic reprogramming of Kinases expands cellular activites of proteins

V. M. Shoba, D. N. P. M. Godage, S. K. Chaudhary, A. Deb, S. U. Siriwardena, A. Choudhary

Angewandte Chemie International Edition. 2022, 61, e202202770

49.

Proximity-Inducing Bifunctional Molecules Beyond PROTACs

S. C. Lai, A.E. Modell, and A. Choudhary

Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective. 2022, 421

48.

Chemical Approaches For Beta-Cell Biology

A. Vetere, V. S. Parekh, A. E. Modell, V. M. Shoba, A. Choudhary, and B. K. Wagner

Nanotechnology for Diabetes Management (RSC book chapter)In press

47.

K. Yamada, A. Deb, V. M. Shoba, D. Lim, B. Maji, A. E. Modell, A. Choudhary

Angewandte Chemie International Edition. 2022, 61, e202201698

 

46.

A. E. Modell, D. Lim, T. Nguyen, V. Sreekanth,  A. Choudhary

Trends in Pharmacological Sciences. 2022, 43, 151.  

2021

45.

T. M. Nguyen, A. Deb, P. Kokkonda, V. Sreekanth, S. K. Chaudhary, P. K. Tiwari, V. M. Shoba, S. Lai, J. Mercer, M. Jan, D. R. Liu, B. L. Ebert, A. Choudhary

Under revision. BioRxiv DOI: 10.1101/2021.11.18.468552

44.

The use of informer sets in screening: Perspective on an efficient strategy to identify new probes

P. A. Clemons, J. Bittker, F. F. Wagner, A. Hands, J. Dahlin, V. Dancik, S. L. Schreiber, A. Choudhary, B. K. Wagner

SLAS Discovery. 2021, 26, 855.

43.

bifunctional modalities for Repurposing protein function

A. E. Modell, S. Lai, T. N. Nguyen, A. Choudhary.

Cell Chemical Biology. 2021, 28, 1081.

42.

S. Kahraman, D. Manna, E. Dirice, B. Maji, J. Small, B. K. Wagner, A. Choudhary*, R. N. Kulkarni*

Life Science Alliance. 2021, 4.4, e202000840.

2020

41.

K.C. Long, L. Alphey, G. J. Annas, C. S. Bloss, K. J. Campbell, J. Champer, C-H Chen, A. Choudhary, G. M. Church, J. P. Collins, K. L. Cooper, J. A. Delborne, O. R. Edwards, C. I. Emerson, K. Esvelt, S. W. Evans, R. M. Friedman, V. M. Gantz, F. Goud, S. Hartley, E. Heitman, J. Hemingway, H. Kanuka, J. Kuzma, J. V. Lavery, Y. Lee, M. Lorenzen, J. E. Lunshof, J. M. Marshall, P. W. Messer, C. Montell, K. A. Oye, M. J. Palmer, P. A. Papthanos, P. N. Paradkar, A. J. Piaggio, J. L. Rasgon, G. Rasic, L. Rudenko, J. R. Saah, M. J. Scott, J. T. Sutton, A. E. Vorsino, O. S. Akbari

Science. 2020, 370, 1417.

Highlighed in: EurekAlert, Phys.org, Science Daily

40.

A. E. Modell, S. U. Siriwardena, V. M. Shoba, X. Li, A. Choudhary.

Current Opinion in Chemical Biology. 2020, 60, 113.

39.

K. Yang, M. Lee, P. A. Jones, S. S. Liu, A. Zhou, J. Xu, V. Sreekanth, J. L. Y. Wu, L.Vo, E. A. Lee, R. Pop, Y. Lee, B. K. Wagner, D. A. Melton, A. Choudhary*, J. M. Karp*

Science Advances. 2020, 6, eabc3207.

38.

V. Sreekanth, Q. Zhou, P. Kokkonda, H. Bermudez-Cabrera, D. Lim, B. Law, B. Holmes, S. Chaudhary, R. Pergu, B. Leger, J. A. Walker, D. Gifford, R. Sherwood, A. Choudhary.  

ACS Central Science. 2020, 6, 2228.

37.

D. Lim, V. Sreekanth, K. J. Cox, B. K. Law, B. K. Wagner, J. M. Karp, and A. Choudhary.

Nature Communications 2020, 11, 4043.

Highlighted in: Faculty of 1000, Nature Bioengineering Blog

36.

S. U. Siriwardena, D. N. P. M. Godage, V. M. Shoba, S. Lai, M. Shi, P. Wu, S. K. Chaudhary, S. L. Schreiber, and A. Choudhary

Journal of the American Chemical Society 2020, 142, 14052 – 14057

Highlighted in: BIOCENTURY, Faculty of 1000

35.

A. E. Modell, S.U. Siriwardena and A. Choudhary

Biochemistry 2020, 59, 1869-1870.

34.

V. L. D. Amo, B. S. Leger, K. J. Cox, S. Gill, A. L. Bishop, G. D. Scanlon, J. A. Walker, V. M. Gantz, A. Choudhary

Cell Reports 2020, 31,107841.

Highlighted in: GEN

33.

M. Lee, B. Maji, D. Manna, S. Kahraman, R. M. Elgamal, J. Small, P. Kokkonda, A. Vetere, J. M. Goldberg, S. J. Lippard, R. N. Kulkarni, B. K. Wagner and A. Choudhary

Journal of the American Chemical Society 2020, 142, 6477 – 6482.

2019

32.

A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9

B. Maji, S. A. Gangopadhyay, M. Lee, M. Shi, P. Wu, R. Heler, B. Mok, D. Lim, S. U. Siriwardena, B. Paul, V. Dančík, A. Vetere, M. F. Mesleh, L. A. Marraffini, D. R. Liu, P. A. Clemons, B. K. Wagner and A. Choudhary

Cell 2019, 177, 1067-1079.

Highlighted in: Cell PressNatureNature MethodsNature Rev Drug DiscoveryBroad Institute,  Harvard GazetteNewScientist, GEN, GenomeWeb, Phys.org, ScienceDaily, MIT Tech Review, In the Pipelineseveral others.

31.

Precision control of CRISPR-Cas9 using light and small molecules.

S. A. Gangopadhyay, K. J. Cox, D. Manna, D. Lim, B. Maji, Q. Zhou, A. Choudhary

Biochemistry 2019, 58, 234-244.

30.

A singular system for dose and spatiotemporal control of CRISPR-Cas9

D. Manna, B. Maji, S. A. Gangopadhyay, K. J. Cox, Q. Zhou, B. K. Law, R. Mazitschek, A. Choudhary

Angewandte Chemie International Edition 2019, 58, 6285-6289.

Highlighted in: BioSpace

29.

A universal method for sensitive and cell-free detection of CRISPR-associated nucleases.

K. J. Cox, H. K. K. Subramanian, C. C. Samaniego, E. Franco*, A. Choudhary*

Chemical Science 2019, 10, 2653 – 2662.

2018

28.

Book Chapter: Kinase Inhibitor Drugs
P. Wu and A. Choudhary
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA.

27.

Special Issue on the Chemical Biology of CRISPR

A. G. Weidmann and A. Choudhary.

ACS Chemical Biology 2018, 13, 283–284.
Highlighted in: IGTRCN

2017

26.

Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.

A. L. Andrew, B, W, Perry, D. C. Card, D. R. Schield, R. P, Ruggiero, Suzanne E. McGaugh, A. Choudhary, S. M. Secor, T. A. Castoe

BMC Genomics 2017, 18, 338.

25.

Multidimensional chemogenic control of CRISPR-Cas9.

B. Maji, C. L. Moore, B. Zetsche, S. E. Volz, F. Zhang, M. D. Shoulders*, A. Choudhary*

Nature Chemical Biology 2017, 13, 9-11.

Highlighted in: Faculty of 1000, News & Views