Skip to content




CRISPR-based therapeutics: Current challenges and future applications

Under revision


harnessing reaction-based probes to preferentially target pancreatic beta-cells and beta-like cells

Under revision


A general approach to identify miniature and cell-permeable anti-cRISPRs

To be submitted


K.C. Long, L. Alphey, G. J. Annas, C. S. Bloss, K. J. Campbell, J. Champer, C-H Chen, A. Choudhary, G. M. Church, J. P. Collins, K. L. Cooper, J. A. Delborne, O. R. Edwards, C. I. Emerson, K. Esvelt, S. W. Evans, R. M. Friedman, V. M. Gantz, F. Goud, S. Hartley, E. Heitman, J. Hemingway, H. Kanuka, J. Kuzma, J. V. Lavery, Y. Lee, M. Lorenzen, J. E. Lunshof, J. M. Marshall, P. W. Messer, C. Montell, K. A. Oye, M. J. Palmer, P. A. Papthanos, P. N. Paradkar, A. J. Piaggio, J. L. Rasgon, G. Rasic, L. Rudenko, J. R. Saah, M. J. Scott, J. T. Sutton, A. E. Vorsino, O. S. Akbari
Science. 2020, 370, 1417.

Highlighed in: EurekAlert,, Science Daily


Chemical And Optical Control Of CRISPR-Associated Nucleases.

A. E. Modell, S. U. Siriwardena, V. M. Shoba, X. Li, A. Choudhary.
Current Opinion in Chemical Biology. In press


K. Yang, M. Lee, P. A. Jones, S. S. Liu, A. Zhou, J. Xu, V. Sreekanth, J. L. Y. Wu, L.Vo, E. A. Lee, R. Pop, Y. Lee, B. K. Wagner, D. A. Melton, A. Choudhary*, J. M. Karp*
Science Advances. In Press


V. Sreekanth, Q. Zhou, P. Kokkonda, H. Bermudez-Cabrera, D. Lim, B. Law, B. Holmes, S. Chaudhary, R. Pergu, B. Leger, J. A. Walker, D. Gifford, R. Sherwood, A. Choudhary.                                                                              ACS Central Science. In Press


D. Lim, V. Sreekanth, K. J. Cox, B. K. Law, B. K. Wagner, J. M. Karp, and A. Choudhary.
Nature Communications 2020, 11, 4043.

Highlighted in: Faculty of 1000, Nature Bioengineering Blog


S. U. Siriwardena, D. N. P. M. Godage, V. M. Shoba, S. Lai, M. Shi, P. Wu, S. K. Chaudhary, S. L. Schreiber, and A. Choudhary
Journal of the American Chemical Society 2020, 142, 14052 – 14057
Highlighted in: BIOCENTURY, Faculty of 1000


A. E. Modell, S.U. Siriwardena and A. Choudhary
Biochemistry 2020, 59, 1869-1870.


V. L. D. Amo, B. S. Leger, K. J. Cox, S. Gill, A. L. Bishop, G. D. Scanlon, J. A. Walker, V. M. Gantz, A. Choudhary
Cell Reports 2020, 31,107841.

Highlighted in: GEN


M. Lee, B. Maji, D. Manna, S. Kahraman, R. M. Elgamal, J. Small, P. Kokkonda, A. Vetere, J. M. Goldberg, S. J. Lippard, R. N. Kulkarni, B. K. Wagner and A. Choudhary
Journal of the American Chemical Society 2020, 142, 6477 – 6482.



A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9

B. Maji, S. A. Gangopadhyay, M. Lee, M. Shi, P. Wu, R. Heler, B. Mok, D. Lim, S. U. Siriwardena, B. Paul, V. Dančík, A. Vetere, M. F. Mesleh, L. A. Marraffini, D. R. Liu, P. A. Clemons, B. K. Wagner and A. Choudhary
Cell 2019, 177, 1067-1079.

Highlighted in: Cell PressNatureNature MethodsNature Rev Drug DiscoveryBroad Institute,  Harvard GazetteNewScientist, GEN, GenomeWeb,, ScienceDaily, MIT Tech Review, In the Pipelineseveral others.


Precision control of CRISPR-Cas9 using light and small molecules.

S. A. Gangopadhyay, K. J. Cox, D. Manna, D. Lim, B. Maji, Q. Zhou, A. Choudhary
Biochemistry 2019, 58, 234-244.


A singular system for dose and spatiotemporal control of CRISPR-Cas9

D. Manna, B. Maji, S. A. Gangopadhyay, K. J. Cox, Q. Zhou, B. K. Law, R. Mazitschek, A. Choudhary
Angewandte Chemie International Edition 2019, 58, 6285-6289.

Highlighted in: BioSpace


A universal method for sensitive and cell-free detection of CRISPR-associated nucleases.

K. J. Cox, H. K. K. Subramanian, C. C. Samaniego, E. Franco and A. Choudhary
Chemical Science 2019, 10, 2653 – 2662.



Book Chapter: Kinase Inhibitor Drugs
P. Wu and A. Choudhary
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA.


Special Issue on the Chemical Biology of CRISPR

A. G. Weidmann and A. Choudhary.
ACS Chemical Biology 2018, 13, 283–284.
Highlighted in: IGTRCN



Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.

A. L. Andrew, B, W, Perry, D. C. Card, D. R. Schield, R. P, Ruggiero, Suzanne E. McGaugh, A. Choudhary, S. M. Secor, T. A. Castoe
BMC Genomics 2017, 18, 338.


Multidimensional chemogenic control of CRISPR-Cas9.

B. Maji, C. L. Moore, B. Zetsche, S. E. Volz, F. Zhang, M. D. Shoulders, A. Choudhary
Nature Chemical Biology 2017, 13, 9-11.
Highlighted in: News & Views