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Publications

2023

63.

Group transfer based Chimeric molecules For Editing Posttranslational Modifications

To be submitted

62.

Recruitment of cytotoxic T cells to cancer cells using chimeric molecules

To be submitted

61.

Homo-Dimerization Mediated Kinase Inhibition Using Bifunctional Molecules

To be submitted

60.

Chimeric Molecules For Phosphorylation-Induced Phase Separation

To be submitted

59.

bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation

W. J. Gibson, A. Sadagopan, V. M. Shoba, A. Choudhary, M. Meyerson, S. L. Schreiber

Journal of the American Chemical Society. doi: 10.1021/jacs.3c06179

58.

Photoswitchable molecular glues enable optical control of transcription factor Degradation

C. J. Arp, M. Reynders, V. Sreekanth, P. Kokkonda, M. Pagano, A. Choudhary, D. Trauner

Submitted. BioRxiv. doi: 10.1101/2023.04.09.536172

 

57.

A molecular glue approach to Control the Half-Life Of CRISPR-based technologies

V. Sreekanth, M. Jan, K. T. Zhao, D. Lim, J. R. Davis, M. McConkey, V. Kovalcik, S. Barkal, B. K. Law, J. Fife, R. Tian, M. E. Vinyard, B. Becerra, M. Kampmann, R. I. Sherwood, L. Pinello, D. R. Liu, B. L. Ebert, A. Choudhary

Submitted. BioRxiv. Doi: 10.1101/2023.03.12.531757

56.

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary,  J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

Nature Chemistry. In press

BioRxiv DOI: 10.1101/2021.11.18.468552

55.

Development and application of chimera platforms for Tyrosine Phosphorylation

R. Pergu, V. M. Shoba, S.K. Chaudhary, D. N. P. M. Godage, A. Deb, S. Singha, V. Anokhina, S. A. Singh, U. Dhawa,  S. U. Siriwardena, A. Choudhary

ACS Central Science. 2023, 9, 1558.

Highlighted: ACS Central Science

54.

Fluorescein-based sensors to purify human alpha cells for functional and transcriptomic analyses

S. Kahraman, K. Shibue, D. F. De Jesus, J. Hu, D. Manna, B. K. Wagner, A. Choudhary, R. N. Kulkarni

eLife. In press. BioRxiv. DOI: 10.11101/2022.11.27.518097

53.

Proximity-inducing modalities: The Past, present, and future

S. Singh, W. Tian, Z. Severance, S. Chaudhary, V. Anokhina, B. Mondal, R. Pergu, P. Singh, U. Dhawa, S. Singha, A. Choudhary

RSC Chemical Society Reviews. 2023, DOI: 10.1039/D2CS00943A 

52.

Excess pancreatic elastase alters acinar-to-B-cell communication by impairing the mechano-signaling and PAR2 pathways

 

G. Basile, A. Vetere, J. Hu, O. Iljaduola, Y. Zhang, K-C. Liu, A. M. Eltony, D. F. De Jesus, F. Fukuda, G. Doherty, C. Leech, O. G. Chepurny, G. G. Holz, S-H, Yun, O. Andersson, A. Choudhary, B. K. Wagner, R. N. Kulkarni

Cell Metabolism. 2023, 35, 1242. 

51.

FALCON Systematically Interrogates Free Fatty Acid Biology And Identifies Novel Mediator Of Lipotoxicity

N. Wieder, J. C. Fried, C. Kim, E-h Sidhom, M. R. Brown, J. L. Marshall, C. Arevalo, M D-Levitt, M. K-Alimova, J. Sieber, K. R. Gabriel, J. Pacheco, C. Clish, H. S. Abbasi, S. Singh, J. Rutter, M. Therrien, H. Yoon, Z. W. Lai, A. Baublis, R. Subramanian, R. Devkota, J. Small, V. Sreekanth, M. Han, D. Lim, A. E. Carpenter, J. Flannick, H. Finucance, M. C. Haigis, M. Claussntizer, E. Sheu, B. Stevens, B. K. Wagner, A. Choudhary, J. L. Shaw, J. L. Pablo, A. Greka

Cell Metabolism. 2023, 35, 887.

2022

50.

A general approach to identify cell-permeable and synthetic anti-cRISPR small molecules

D. Lim, Q. Zhou, K. J. Cox, B. K. Law, M. Lee, P. Kokkonda, V. Sreekanth, R. Pergu, S. K. Chaudhary, S. A. Gangopadhyaya, B. Maji, S. Lai, Y. Amako, D. B. Thompson, H. K. Subramanian, M. F. Mesleh, V. Dancik, P. A. Clemons, B. K. Wagner, C. M. Woo, G. M. Church, A. Choudhary

Nature Cell Biology. 2022, 24, 1766

 

49.

Synthetic reprogramming of Kinases expands cellular activites of proteins

V. M. Shoba, D. N. P. M. Godage, S. K. Chaudhary, A. Deb, S. U. Siriwardena, A. Choudhary

Angewandte Chemie International Edition. 2022, 61, e202202770

48.

Proximity-Inducing Bifunctional Molecules Beyond PROTACs

S. C. Lai, A.E. Modell, and A. Choudhary

Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective. 2022, 421

47.

Chemical Approaches For Beta-Cell Biology

A. Vetere, V. S. Parekh, A. E. Modell, V. M. Shoba, A. Choudhary, and B. K. Wagner

Nanotechnology for Diabetes Management (RSC book chapter)In press

46.

K. Yamada, A. Deb, V. M. Shoba, D. Lim, B. Maji, A. E. Modell, A. Choudhary

Angewandte Chemie International Edition. 2022, 61, e202201698

 

45.

A. E. Modell, D. Lim, T. Nguyen, V. Sreekanth,  A. Choudhary

Trends in Pharmacological Sciences. 2022, 43, 151.  

2021

44.

The use of informer sets in screening: Perspective on an efficient strategy to identify new probes

P. A. Clemons, J. Bittker, F. F. Wagner, A. Hands, J. Dahlin, V. Dancik, S. L. Schreiber, A. Choudhary, B. K. Wagner

SLAS Discovery. 2021, 26, 855.

43.

bifunctional modalities for Repurposing protein function

A. E. Modell, S. Lai, T. N. Nguyen, A. Choudhary.

Cell Chemical Biology. 2021, 28, 1081.

42.

S. Kahraman, D. Manna, E. Dirice, B. Maji, J. Small, B. K. Wagner, A. Choudhary*, R. N. Kulkarni*

Life Science Alliance. 2021, 4.4, e202000840.

2020

41.

K.C. Long, L. Alphey, G. J. Annas, C. S. Bloss, K. J. Campbell, J. Champer, C-H Chen, A. Choudhary, G. M. Church, J. P. Collins, K. L. Cooper, J. A. Delborne, O. R. Edwards, C. I. Emerson, K. Esvelt, S. W. Evans, R. M. Friedman, V. M. Gantz, F. Goud, S. Hartley, E. Heitman, J. Hemingway, H. Kanuka, J. Kuzma, J. V. Lavery, Y. Lee, M. Lorenzen, J. E. Lunshof, J. M. Marshall, P. W. Messer, C. Montell, K. A. Oye, M. J. Palmer, P. A. Papthanos, P. N. Paradkar, A. J. Piaggio, J. L. Rasgon, G. Rasic, L. Rudenko, J. R. Saah, M. J. Scott, J. T. Sutton, A. E. Vorsino, O. S. Akbari

Science. 2020, 370, 1417.

Highlighed in: EurekAlert, Phys.org, Science Daily

40.

A. E. Modell, S. U. Siriwardena, V. M. Shoba, X. Li, A. Choudhary.

Current Opinion in Chemical Biology. 2020, 60, 113.

39.

K. Yang, M. Lee, P. A. Jones, S. S. Liu, A. Zhou, J. Xu, V. Sreekanth, J. L. Y. Wu, L.Vo, E. A. Lee, R. Pop, Y. Lee, B. K. Wagner, D. A. Melton, A. Choudhary*, J. M. Karp*

Science Advances. 2020, 6, eabc3207.

38.

V. Sreekanth, Q. Zhou, P. Kokkonda, H. Bermudez-Cabrera, D. Lim, B. Law, B. Holmes, S. Chaudhary, R. Pergu, B. Leger, J. A. Walker, D. Gifford, R. Sherwood, A. Choudhary.  

ACS Central Science. 2020, 6, 2228.

37.

D. Lim, V. Sreekanth, K. J. Cox, B. K. Law, B. K. Wagner, J. M. Karp, and A. Choudhary.

Nature Communications 2020, 11, 4043.

Highlighted in: Faculty of 1000, Nature Bioengineering Blog

36.

S. U. Siriwardena, D. N. P. M. Godage, V. M. Shoba, S. Lai, M. Shi, P. Wu, S. K. Chaudhary, S. L. Schreiber, and A. Choudhary

Journal of the American Chemical Society 2020, 142, 14052 – 14057

Highlighted in: BIOCENTURY, Faculty of 1000

35.

A. E. Modell, S.U. Siriwardena and A. Choudhary

Biochemistry 2020, 59, 1869-1870.

34.

V. L. D. Amo, B. S. Leger, K. J. Cox, S. Gill, A. L. Bishop, G. D. Scanlon, J. A. Walker, V. M. Gantz, A. Choudhary

Cell Reports 2020, 31,107841.

Highlighted in: GEN

33.

M. Lee, B. Maji, D. Manna, S. Kahraman, R. M. Elgamal, J. Small, P. Kokkonda, A. Vetere, J. M. Goldberg, S. J. Lippard, R. N. Kulkarni, B. K. Wagner and A. Choudhary

Journal of the American Chemical Society 2020, 142, 6477 – 6482.

2019

32.

A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9

B. Maji, S. A. Gangopadhyay, M. Lee, M. Shi, P. Wu, R. Heler, B. Mok, D. Lim, S. U. Siriwardena, B. Paul, V. Dančík, A. Vetere, M. F. Mesleh, L. A. Marraffini, D. R. Liu, P. A. Clemons, B. K. Wagner and A. Choudhary

Cell 2019, 177, 1067-1079.

Highlighted in: Cell PressNatureNature MethodsNature Rev Drug DiscoveryBroad Institute,  Harvard GazetteNewScientist, GEN, GenomeWeb, Phys.org, ScienceDaily, MIT Tech Review, In the Pipelineseveral others.

31.

Precision control of CRISPR-Cas9 using light and small molecules.

S. A. Gangopadhyay, K. J. Cox, D. Manna, D. Lim, B. Maji, Q. Zhou, A. Choudhary

Biochemistry 2019, 58, 234-244.

30.

A singular system for dose and spatiotemporal control of CRISPR-Cas9

D. Manna, B. Maji, S. A. Gangopadhyay, K. J. Cox, Q. Zhou, B. K. Law, R. Mazitschek, A. Choudhary

Angewandte Chemie International Edition 2019, 58, 6285-6289.

Highlighted in: BioSpace

29.

A universal method for sensitive and cell-free detection of CRISPR-associated nucleases.

K. J. Cox, H. K. K. Subramanian, C. C. Samaniego, E. Franco*, A. Choudhary*

Chemical Science 2019, 10, 2653 – 2662.

2018

28.

Book Chapter: Kinase Inhibitor Drugs
P. Wu and A. Choudhary
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA.

27.

Special Issue on the Chemical Biology of CRISPR

A. G. Weidmann and A. Choudhary.

ACS Chemical Biology 2018, 13, 283–284.
Highlighted in: IGTRCN

2017

26.

Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.

A. L. Andrew, B, W, Perry, D. C. Card, D. R. Schield, R. P, Ruggiero, Suzanne E. McGaugh, A. Choudhary, S. M. Secor, T. A. Castoe

BMC Genomics 2017, 18, 338.

25.

Multidimensional chemogenic control of CRISPR-Cas9.

B. Maji, C. L. Moore, B. Zetsche, S. E. Volz, F. Zhang, M. D. Shoulders*, A. Choudhary*

Nature Chemical Biology 2017, 13, 9-11.

Highlighted in: Faculty of 1000, News & Views