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Precision Control Of The Half-Life Of CRISPR-Based Systems In Vivo​

V. Sreekanth, M. Jan, K. T. Zhao, D. Lim, J. R. Davis, M. McConkey, V. Kovalcik, S. Barkal, B. K. Law, J. Fife, R. Tian, M. E. Vinyard, B. Becerra, M. Kampmann, R. I. Sherwood, L. Pinello, D. R. Liu, B. L. Ebert, A. Choudhary



Induction Of Tyrosine Phosphorylation By Chimeric Small Molecules

R. Pergu, V. M. Shoba, S.K. Chaudhary, D. N. P. M. Godage, A. Deb, S. Singha, V. Anokhina, S. A. Singh, U. Dhawa,  S. U. Siriwardena, A. Choudhary




Isoform-Specific Recruitment Of Kinases For Phosphorylation Induction

S. Lai, R. Pergu, P. Kokkonda, P. Tiwari, A. Choudhary



Homo-dimerization mediated kinase inhibition using bifunctional molecules


A multiplexed platform enables systematic interogation of fatty acid biology and uncovers mechanism of lipotoxicity

Under review


A general approach to identify cell-permeable and synthetic anti-cRISPR small molecules

D. Lim, Q. Zhou, K. J. Cox, B. K. Law, M. Lee, P. Kokkonda, V. Sreekanth, R. Pergu, S. K. Chaudhary, S. A. Gangopadhyaya, B. Maji, S. Lai, Y. Amako, D. B. Thompson, H. K. Subramanian, M. F. Mesleh, V. Dancik, P. A. Clemons, B. K. Wagner, C. M. Woo, G. M. Church, A. Choudhary

Nature Cell Biology. In Press


Synthetic reprogramming of Kinases expands cellular activites of proteins

V. M. Shoba, D. N. P. M. Godage, S. K. Chaudhary, A. Deb, S. U. Siriwardena, A. Choudhary

Angewandte Chemie International Edition. 2022, 61, e202202770


Proximity-Inducing Bifunctional Molecules Beyond PROTACs

S. C. Lai, A.E. Modell, and A. Choudhary

Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective. 2022, 421


Chemical Approaches For Beta-Cell Biology

A. Vetere, V. S. Parekh, A. E. Modell, V. M. Shoba, A. Choudhary, and B. K. Wagner

Nanotechnology for Diabetes Management (RSC book chapter)In press


K. Yamada, A. Deb, V. M. Shoba, D. Lim, B. Maji, A. E. Modell, A. Choudhary

Angewandte Chemie International Edition. 2022, 61, e202201698



A. E. Modell, D. Lim, T. Nguyen, V. Sreekanth,  A. Choudhary

Trends in Pharmacological Sciences. 2022, 43, 151.  



T. M. Nguyen, A. Deb, P. Kokkonda, V. Sreekanth, S. K. Chaudhary, P. K. Tiwari, V. M. Shoba, S. Lai, J. Mercer, M. Jan, D. R. Liu, B. L. Ebert, A. Choudhary

Under revision. BioRxiv DOI: 10.1101/2021.11.18.468552


The use of informer sets in screening: Perspective on an efficient strategy to identify new probes

P. A. Clemons, J. Bittker, F. F. Wagner, A. Hands, J. Dahlin, V. Dancik, S. L. Schreiber, A. Choudhary, B. K. Wagner

SLAS Discovery. 2021, 26, 855.


bifunctional modalities for Repurposing protein function

A. E. Modell, S. Lai, T. N. Nguyen, A. Choudhary.

Cell Chemical Biology. 2021, 28, 1081.


S. Kahraman, D. Manna, E. Dirice, B. Maji, J. Small, B. K. Wagner, A. Choudhary*, R. N. Kulkarni*

Life Science Alliance. 2021, 4.4, e202000840.



K.C. Long, L. Alphey, G. J. Annas, C. S. Bloss, K. J. Campbell, J. Champer, C-H Chen, A. Choudhary, G. M. Church, J. P. Collins, K. L. Cooper, J. A. Delborne, O. R. Edwards, C. I. Emerson, K. Esvelt, S. W. Evans, R. M. Friedman, V. M. Gantz, F. Goud, S. Hartley, E. Heitman, J. Hemingway, H. Kanuka, J. Kuzma, J. V. Lavery, Y. Lee, M. Lorenzen, J. E. Lunshof, J. M. Marshall, P. W. Messer, C. Montell, K. A. Oye, M. J. Palmer, P. A. Papthanos, P. N. Paradkar, A. J. Piaggio, J. L. Rasgon, G. Rasic, L. Rudenko, J. R. Saah, M. J. Scott, J. T. Sutton, A. E. Vorsino, O. S. Akbari

Science. 2020, 370, 1417.

Highlighed in: EurekAlert,, Science Daily


A. E. Modell, S. U. Siriwardena, V. M. Shoba, X. Li, A. Choudhary.

Current Opinion in Chemical Biology. 2020, 60, 113.


K. Yang, M. Lee, P. A. Jones, S. S. Liu, A. Zhou, J. Xu, V. Sreekanth, J. L. Y. Wu, L.Vo, E. A. Lee, R. Pop, Y. Lee, B. K. Wagner, D. A. Melton, A. Choudhary*, J. M. Karp*

Science Advances. 2020, 6, eabc3207.


V. Sreekanth, Q. Zhou, P. Kokkonda, H. Bermudez-Cabrera, D. Lim, B. Law, B. Holmes, S. Chaudhary, R. Pergu, B. Leger, J. A. Walker, D. Gifford, R. Sherwood, A. Choudhary.  

ACS Central Science. 2020, 6, 2228.


D. Lim, V. Sreekanth, K. J. Cox, B. K. Law, B. K. Wagner, J. M. Karp, and A. Choudhary.

Nature Communications 2020, 11, 4043.

Highlighted in: Faculty of 1000, Nature Bioengineering Blog


S. U. Siriwardena, D. N. P. M. Godage, V. M. Shoba, S. Lai, M. Shi, P. Wu, S. K. Chaudhary, S. L. Schreiber, and A. Choudhary

Journal of the American Chemical Society 2020, 142, 14052 – 14057

Highlighted in: BIOCENTURY, Faculty of 1000


A. E. Modell, S.U. Siriwardena and A. Choudhary

Biochemistry 2020, 59, 1869-1870.


V. L. D. Amo, B. S. Leger, K. J. Cox, S. Gill, A. L. Bishop, G. D. Scanlon, J. A. Walker, V. M. Gantz, A. Choudhary

Cell Reports 2020, 31,107841.

Highlighted in: GEN


M. Lee, B. Maji, D. Manna, S. Kahraman, R. M. Elgamal, J. Small, P. Kokkonda, A. Vetere, J. M. Goldberg, S. J. Lippard, R. N. Kulkarni, B. K. Wagner and A. Choudhary

Journal of the American Chemical Society 2020, 142, 6477 – 6482.



A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9

B. Maji, S. A. Gangopadhyay, M. Lee, M. Shi, P. Wu, R. Heler, B. Mok, D. Lim, S. U. Siriwardena, B. Paul, V. Dančík, A. Vetere, M. F. Mesleh, L. A. Marraffini, D. R. Liu, P. A. Clemons, B. K. Wagner and A. Choudhary

Cell 2019, 177, 1067-1079.

Highlighted in: Cell PressNatureNature MethodsNature Rev Drug DiscoveryBroad Institute,  Harvard GazetteNewScientist, GEN, GenomeWeb,, ScienceDaily, MIT Tech Review, In the Pipelineseveral others.


Precision control of CRISPR-Cas9 using light and small molecules.

S. A. Gangopadhyay, K. J. Cox, D. Manna, D. Lim, B. Maji, Q. Zhou, A. Choudhary

Biochemistry 2019, 58, 234-244.


A singular system for dose and spatiotemporal control of CRISPR-Cas9

D. Manna, B. Maji, S. A. Gangopadhyay, K. J. Cox, Q. Zhou, B. K. Law, R. Mazitschek, A. Choudhary

Angewandte Chemie International Edition 2019, 58, 6285-6289.

Highlighted in: BioSpace


A universal method for sensitive and cell-free detection of CRISPR-associated nucleases.

K. J. Cox, H. K. K. Subramanian, C. C. Samaniego, E. Franco*, A. Choudhary*

Chemical Science 2019, 10, 2653 – 2662.



Book Chapter: Kinase Inhibitor Drugs
P. Wu and A. Choudhary
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA.


Special Issue on the Chemical Biology of CRISPR

A. G. Weidmann and A. Choudhary.

ACS Chemical Biology 2018, 13, 283–284.
Highlighted in: IGTRCN



Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.

A. L. Andrew, B, W, Perry, D. C. Card, D. R. Schield, R. P, Ruggiero, Suzanne E. McGaugh, A. Choudhary, S. M. Secor, T. A. Castoe

BMC Genomics 2017, 18, 338.


Multidimensional chemogenic control of CRISPR-Cas9.

B. Maji, C. L. Moore, B. Zetsche, S. E. Volz, F. Zhang, M. D. Shoulders*, A. Choudhary*

Nature Chemical Biology 2017, 13, 9-11.

Highlighted in: Faculty of 1000, News & Views