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Updates from the lab

The great @LynJonesChemBio and I partnered with an exceptional group of experts to bring you a book that talks about how thinking about protein homeostasis more holistically could help us find future medicines!
A gratitude 馃У

Cool findings from @DanNomura @JPapatzimas @EthanToriki about a covalent handle to recruit RNF126 for targeted protein degradation. We will soon report a similar approach for phosphorylation (or PTM induction/removal). Exciting times for #covalentrecruitment for PTM editing!

Dan Nomura@DanNomura

Excited to present our @biorxivpreprint on chemical rational design of molecular glue degraders through a covalent handle targeting RNF126! Congrats to @EthanToriki & @JPapatzimas who led work w/@NovartisScience! & thanks to @TheMarkFdn ! https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1

Excited to present our @biorxivpreprint on chemical rational design of molecular glue degraders through a covalent handle targeting RNF126! Congrats to @EthanToriki & @JPapatzimas who led work w/@NovartisScience! & thanks to @TheMarkFdn ! https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1

Congratulations to team Saki @hopeflaxman @Big_Fish_Linda @nandinivsr Hannah Dacheng and collaborators @MattRPratt and Binyou! This was a true collaborative effort in the group to discover a degron for cereblon! https://rdcu.be/cXTkl

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