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Updates from the lab

In @angew_chem, we report Phosphorylation-inducing chimeric small molecules (PHICS) that rewired Protein Kinase C (PKC) to act at a new cellular location and phosphorylate non-native substrates or new sites on a substrate, resulting in new bioactivities. https://onlinelibrary.wiley.com/doi/10.1002/anie.202202770

The Best Scientists 🧵

I have heard a lot about the Best Scientists 🧑‍🔬

Maybe the best scientists…
make impactful discoveries,
publish in gilded journals,
garner millions in funding,
with lots of indirects.
And prizes, all the prizes🏆

And everybody respects them.

OR…

Out in @angew_chem our paper about the rational design of ionophores, the small molecules that can transport metal ions into cells. Ionophores have widespread applications but remain underdeveloped.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202201698

Standing at the spot @Penn where Drs. Kati Kariko (@kkariko) & Drew Weissman (@Weissmanlab) first met. This spot had a photocopying machine where “they struck up their first conversations” ~25 years ago that would eventually lead to the COVID-19 mRNA vaccine.

Ukraine is a global leader in the production of molecules used to fine-tune the design of new drugs. Russia’s attacks have put the industry and its scientists at risk. https://www.wsj.com/articles/ukraines-world-class-drug-molecule-industry-imperiled-by-russia-invasion-11647784800

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