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Updates from the lab

Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X https://www.sciencedirect.com/science/article/pii/S0092867422014702

Very disappointed to see this new paper in @NatureCancer on a clinical trial with “HDAC6 inhibitor” ricolinostat. The paper fails to mention three recent reports demonstrating that this drug exhibits pervasive off-target toxicity.

The great @LynJonesChemBio and I partnered with an exceptional group of experts to bring you a book that talks about how thinking about protein homeostasis more holistically could help us find future medicines!
A gratitude 🧵

Cool findings from @DanNomura @JPapatzimas @EthanToriki about a covalent handle to recruit RNF126 for targeted protein degradation. We will soon report a similar approach for phosphorylation (or PTM induction/removal). Exciting times for #covalentrecruitment for PTM editing!

Dan Nomura@DanNomura

Excited to present our @biorxivpreprint on chemical rational design of molecular glue degraders through a covalent handle targeting RNF126! Congrats to @EthanToriki & @JPapatzimas who led work w/@NovartisScience! & thanks to @TheMarkFdn ! https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1

Excited to present our @biorxivpreprint on chemical rational design of molecular glue degraders through a covalent handle targeting RNF126! Congrats to @EthanToriki & @JPapatzimas who led work w/@NovartisScience! & thanks to @TheMarkFdn ! https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1

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