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Updates from the lab

Reduced off-targets for #PROTACs – important preprint by @ChoudharyLab.
Chemical modification on C5 position for your #CRBN based #PROTAC may limit degradation of ZNF containing transcription factor. A potential explanation for @ArvinasInc “magic fluoride” in #ARV110. https://twitter.com/ChoudharyLab/status/1462161092646371332

The Amit Choudhary Lab@ChoudharyLab

Excited to share our preprint on PROTAC linkerology: Proteolysis Targeting Chimeras (PROTACs) With Reduced Off-targets: https://tinyurl.com/u4ktc9u3

Excited to share our preprint on PROTAC linkerology: Proteolysis Targeting Chimeras (PROTACs) With Reduced Off-targets: https://tinyurl.com/u4ktc9u3

You know targeted drug delivery – approaches that enrich drugs in specific tissues. Our latest work shows you can target drugs with even higher precision with DNA nanotech – send them to a specific organelle in a specific cell type: Next-gen targeting, let’s say. 1/n

Every paper should have a small section at the end called “Author speculation” where the authors get a paragraph or two to say anything they want about what they think the results mean without reviewer input & it’s made abundantly clear that this is wild speculation on their part

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